Pattern electroretinogram in neuromyelitis optica and multiple sclerosis with or without optic neuritis and its correlation with FD-OCT and perimetry
Identifieur interne : 000337 ( Main/Exploration ); précédent : 000336; suivant : 000338Pattern electroretinogram in neuromyelitis optica and multiple sclerosis with or without optic neuritis and its correlation with FD-OCT and perimetry
Auteurs : Kenzo Hokazono [Brésil, États-Unis] ; Ali S. Raza [États-Unis] ; Maria K. Oyamada [Brésil] ; Donald C. Hood [États-Unis] ; Mário L. R. Monteiro [Brésil]Source :
- Documenta Ophthalmologica [ 0012-4486 ] ; 2013.
English descriptors
- Teeft :
- Abnormality, Amplitude, Amplitude parameter, Aroc, Arocs, Axonal, Axonal loss, Check size, Check stimulus, Chiasmal compression, Coherence, Columbia university, Correlation coefficient, Current study, Datum, Electroretinogram, Ganglion, Glaucoma, Healthy control, In nuclear layer, Largest arocs, Letm, Letm eye, Macular, Macular thickness, Monteiro, Multiple sclerosis, Myelitis, Neuritis, Neurol, Neuromyelitis, Neuromyelitis optica, Normal control, Normal eye, Ophthalmol, Ophthalmology, Optic, Optic nerve, Optic neuritis, Optica, Optical coherence tomography, Parameter, Pattern electroretinogram, Pattern electroretinography, Peak time, Perg, Perg amplitude, Perg amplitude parameter, Perg parameter, Peripapillary, Peripapillary rnfl, Peripapillary rnfl thickness, Present study, Previous study, Retinal, Rgcl, Rnfl, Rnfl thickness, Sclerosis, Segmented, Sensitivity loss, Significant correlation, Significant difference, Similar performance, Spinal cord, Statistical significance, Test point, Thickness value, Tomography, Total retinal thickness, Visual acuity, Visual field.
Abstract
Abstract: Purpose: To evaluate the ability of transient pattern electroretinogram (PERG) parameters to differentiate between eyes of patients with neuromyelitis optica (NMO), longitudinally extensive transverse myelitis (LETM), multiple sclerosis with optic neuritis (MS + ON), multiple sclerosis without optic neuritis (MS − ON), and controls, to compare PERG and OCT with regard to discrimination ability, and to assess the correlation between PERG, FD-OCT, and visual field measurements (VFs). Methods: Visual field measurements and full-field stimulation PERGs based on both 48- and 14-min checks were obtained from patients with MS (n = 28), NMO (n = 20), LETM (n = 18), and controls (n = 26). In addition, FD-OCT peripapillary retinal nerve fiber layer (RNFL) and segmented macular layer measurements were obtained and their correlation coefficients were determined. Results: Compared to controls, PERG amplitude measurements were significantly reduced in eyes with NMO and MS + ON, but not in eyes with LETM and MS − ON. PERG amplitudes were significantly smaller in NMO and MS + ON eyes than in MS − ON eyes. PERG and OCT performance was similar except in NMO eyes where macular thickness parameters were more efficient at detecting abnormalities. A significant correlation was found between N95 amplitude values and OCT-measured macular ganglion cell layer thickness, total retinal thickness, and temporal peripapillary RNFL thickness. PERG amplitude was also significantly associated with VF sensitivity loss. No statistically significant difference was observed with regard to the best-performing parameters of the two methods. Conclusions: Pattern electroretinogram measurements were able to detect RNFL loss in MS + ON and NMO eyes, with a performance comparable to OCT. PERG amplitude measurements were reasonably well correlated with OCT-measured parameters.
Url:
DOI: 10.1007/s10633-013-9401-2
Affiliations:
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Oyamada</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33), University of São Paulo Medical School, Av. Angélica 1757 conj. 61, 01227-200, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Hood, Donald C" sort="Hood, Donald C" uniqKey="Hood D" first="Donald C." last="Hood">Donald C. Hood</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Monteiro, Mario L R" sort="Monteiro, Mario L R" uniqKey="Monteiro M" first="Mário L. R." last="Monteiro">Mário L. R. Monteiro</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33), University of São Paulo Medical School, Av. Angélica 1757 conj. 61, 01227-200, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Brésil</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Documenta Ophthalmologica</title><title level="j" type="abbrev">Doc Ophthalmol</title><idno type="ISSN">0012-4486</idno><idno type="eISSN">1573-2622</idno><imprint><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-SWLMH5L1-1">Springer Berlin Heidelberg</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2013">2013</date><biblScope unit="vol" from="127" to="127">127</biblScope><biblScope unit="issue" from="3" to="3">3</biblScope><biblScope unit="page" from="201">201</biblScope><biblScope unit="page" to="215">215</biblScope></imprint><idno type="ISSN">0012-4486</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0012-4486</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term><term>Amplitude</term><term>Amplitude parameter</term><term>Aroc</term><term>Arocs</term><term>Axonal</term><term>Axonal loss</term><term>Check size</term><term>Check stimulus</term><term>Chiasmal compression</term><term>Coherence</term><term>Columbia university</term><term>Correlation coefficient</term><term>Current study</term><term>Datum</term><term>Electroretinogram</term><term>Ganglion</term><term>Glaucoma</term><term>Healthy control</term><term>In nuclear layer</term><term>Largest arocs</term><term>Letm</term><term>Letm eye</term><term>Macular</term><term>Macular thickness</term><term>Monteiro</term><term>Multiple sclerosis</term><term>Myelitis</term><term>Neuritis</term><term>Neurol</term><term>Neuromyelitis</term><term>Neuromyelitis optica</term><term>Normal control</term><term>Normal eye</term><term>Ophthalmol</term><term>Ophthalmology</term><term>Optic</term><term>Optic nerve</term><term>Optic neuritis</term><term>Optica</term><term>Optical coherence tomography</term><term>Parameter</term><term>Pattern electroretinogram</term><term>Pattern electroretinography</term><term>Peak time</term><term>Perg</term><term>Perg amplitude</term><term>Perg amplitude parameter</term><term>Perg parameter</term><term>Peripapillary</term><term>Peripapillary rnfl</term><term>Peripapillary rnfl thickness</term><term>Present study</term><term>Previous study</term><term>Retinal</term><term>Rgcl</term><term>Rnfl</term><term>Rnfl thickness</term><term>Sclerosis</term><term>Segmented</term><term>Sensitivity loss</term><term>Significant correlation</term><term>Significant difference</term><term>Similar performance</term><term>Spinal cord</term><term>Statistical significance</term><term>Test point</term><term>Thickness value</term><term>Tomography</term><term>Total retinal thickness</term><term>Visual acuity</term><term>Visual field</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Purpose: To evaluate the ability of transient pattern electroretinogram (PERG) parameters to differentiate between eyes of patients with neuromyelitis optica (NMO), longitudinally extensive transverse myelitis (LETM), multiple sclerosis with optic neuritis (MS + ON), multiple sclerosis without optic neuritis (MS − ON), and controls, to compare PERG and OCT with regard to discrimination ability, and to assess the correlation between PERG, FD-OCT, and visual field measurements (VFs). Methods: Visual field measurements and full-field stimulation PERGs based on both 48- and 14-min checks were obtained from patients with MS (n = 28), NMO (n = 20), LETM (n = 18), and controls (n = 26). In addition, FD-OCT peripapillary retinal nerve fiber layer (RNFL) and segmented macular layer measurements were obtained and their correlation coefficients were determined. Results: Compared to controls, PERG amplitude measurements were significantly reduced in eyes with NMO and MS + ON, but not in eyes with LETM and MS − ON. PERG amplitudes were significantly smaller in NMO and MS + ON eyes than in MS − ON eyes. PERG and OCT performance was similar except in NMO eyes where macular thickness parameters were more efficient at detecting abnormalities. A significant correlation was found between N95 amplitude values and OCT-measured macular ganglion cell layer thickness, total retinal thickness, and temporal peripapillary RNFL thickness. PERG amplitude was also significantly associated with VF sensitivity loss. No statistically significant difference was observed with regard to the best-performing parameters of the two methods. Conclusions: Pattern electroretinogram measurements were able to detect RNFL loss in MS + ON and NMO eyes, with a performance comparable to OCT. PERG amplitude measurements were reasonably well correlated with OCT-measured parameters.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>État de New York</li><li>État de São Paulo</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Hokazono, Kenzo" sort="Hokazono, Kenzo" uniqKey="Hokazono K" first="Kenzo" last="Hokazono">Kenzo Hokazono</name></region><name sortKey="Monteiro, Mario L R" sort="Monteiro, Mario L R" uniqKey="Monteiro M" first="Mário L. R." last="Monteiro">Mário L. R. Monteiro</name><name sortKey="Monteiro, Mario L R" sort="Monteiro, Mario L R" uniqKey="Monteiro M" first="Mário L. R." last="Monteiro">Mário L. R. Monteiro</name><name sortKey="Oyamada, Maria K" sort="Oyamada, Maria K" uniqKey="Oyamada M" first="Maria K." last="Oyamada">Maria K. Oyamada</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Hokazono, Kenzo" sort="Hokazono, Kenzo" uniqKey="Hokazono K" first="Kenzo" last="Hokazono">Kenzo Hokazono</name></region><name sortKey="Hood, Donald C" sort="Hood, Donald C" uniqKey="Hood D" first="Donald C." last="Hood">Donald C. Hood</name><name sortKey="Hood, Donald C" sort="Hood, Donald C" uniqKey="Hood D" first="Donald C." last="Hood">Donald C. Hood</name><name sortKey="Raza, Ali S" sort="Raza, Ali S" uniqKey="Raza A" first="Ali S." last="Raza">Ali S. Raza</name><name sortKey="Raza, Ali S" sort="Raza, Ali S" uniqKey="Raza A" first="Ali S." last="Raza">Ali S. 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